ALPHA MANGOSTIN PDF

Toxicol In Vitro. Epub Sep 6. Alpha-mangostin, an active compound in Garcinia mangostana, abrogates anoikis-resistance in human hepatocellular carcinoma cells. Electronic address: ratana.

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The dilution data of the sheet for your reference. Protocol Bioorg Med Chem. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. In the current study, we investigated the mechanism of apoptosis induced by alpha-Mangostin in HL60 cells. On the other hand, alpha-Mangostin-treatment did not affect expression of bcl-2 family proteins and activation of MAP kinases.

These findings indicate that alpha-Mangostin preferentially targets mitochondria in the early phase, resulting in indication of apoptosis in HL60 cells. Furthermore, we examined the structure-activity relationship between xanthone derivatives including alpha-Mangostin and the potency of deltapsim-loss in HL60 cells. Interestingly, replacement of hydroxyl group by methoxy group remarkably decreased its potency. It was also shown that the cytotoxicity substantially correlated with deltapsim decrease.

Cell Biochem Biophys. Also, a dose-dependent inhibition on the binding abilities of NF-kappaB by alpha-Mangostin treatment was further observed. Eur J Pharmacol. Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist. But KCl-, phenylephrine- or carbachol-induced contractions were not affected by alpha-Mangostin.

The concentration-contractile response curve for histamine was shifted to the right in a parallel manner by alpha-Mangostin. In the presence of chlorpheniramine, a histamine H1 receptor antagonist, alpha-Mangostin did not affect the relaxation of the rabbit aorta induced by histamine. In the guinea-pig trachea, alpha-Mangostin had no effect on the relaxation induced by dimaprit, a histamine H2 receptor agonist.

Kinetic analysis of [3H]mepyramine binding indicated the competitive inhibition by alpha-Mangostin. Cell Research: Exp Toxicol Pathol. ROS scavenging capacity and neuroprotective effect of alpha-mangostin against 3-nitropropionic acid in cerebellar granule neurons. The reactive oxygen species ROS scavenging capacity and the potential protective effect of alpha-Mangostin against the mitochondrial toxin 3-nitropropionic acid 3-NP in primary cultures of cerebellar granule neurons CGNs were studied in the present work.

It was found that alpha-Mangostin was able to scavenge in a concentration-dependent way singlet oxygen, superoxide anion and peroxynitrite anion. In contrast, alpha-Mangostin was unable to scavenge hydroxyl radicals and hydrogen peroxide. Furthermore, alpha-Mangostin was able to ameliorate in a concentration-dependent way the neuronal death induced by 3-NP. This protective effect was associated with an amelioration of 3-NP-induced reactive oxygen species formation. Animal Research: Biol Res Nurs.

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